# Data tables for 2x2 interior loops
# Free energies at 37 degrees for RNA
# Data arrangement:
#
# 5' ------> 3'
# A X1 Y1 A
# U X2 Y2 U
# 3' <------ 5'
#
# Y-->
# ----------------------------------------------------------------------------------------------------------------------------
# (X) A A A A C C C C G G G G U U U U
# | A C G U A C G U A C G U A C G U
# V ----------------------------------------------------------------------------------------------------------------------------
# (AA) 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 1.8 2.3 1.2 2.3 2.8 2.5 2.8 2.5
# (AC) 2.6 2.2 1.6 2.2 2.6 2.6 2.6 2.6 1.7 2.2 1.1 2.2 2.6 2.3 2.6 1.8
# (AG) 2.2 1.8 1.2 1.8 2.2 2.8 2.2 2.8 1.3 1.8 2.0 1.8 2.2 2.5 2.2 1.4
# (AU) 2.6 2.2 1.6 2.2 2.6 2.6 2.6 2.6 1.7 2.2 1.1 2.2 2.6 2.3 2.6 1.8
# (CA) 2.5 2.1 1.5 2.1 2.5 2.5 2.5 2.5 1.6 2.1 1.0 2.1 2.5 2.2 2.5 1.7
# (CC) 2.6 2.1 2.1 2.1 2.6 2.6 2.6 2.6 2.2 2.1 1.0 2.1 2.6 2.3 2.6 1.7
# (CG) 2.5 2.1 1.5 2.1 2.5 2.5 2.5 2.5 1.6 2.1 1.0 2.1 2.5 2.2 2.5 1.7
# (CU) 2.6 2.1 2.1 2.1 2.6 2.6 2.6 2.6 2.2 2.1 1.0 2.1 2.6 2.3 2.6 1.7
# (GA) 1.5 1.1 0.5 1.1 1.5 2.1 1.5 2.1 0.6 1.1 1.3 1.1 1.5 1.8 1.5 0.7
# (GC) 2.6 2.2 1.6 2.2 2.6 2.6 2.6 2.6 1.7 2.2 1.1 2.2 2.6 2.3 2.6 1.8
# (GG) 1.0 0.6 1.3 0.6 1.0 1.0 1.0 1.0 1.4 0.6 2.1 0.6 1.0 0.7 1.0 1.5
# (GU) 2.6 2.2 1.6 2.2 2.6 2.6 2.6 2.6 1.7 2.2 1.1 2.2 2.6 2.3 2.6 1.8
# (UA) 2.5 2.1 1.5 2.1 2.5 2.5 2.5 2.5 1.6 2.1 1.0 2.1 2.5 2.2 2.5 1.7
# (UC) 2.6 2.1 2.1 2.1 2.6 2.6 2.6 2.6 2.2 2.1 1.0 2.1 2.6 2.3 2.6 1.7
# (UG) 2.5 2.1 1.5 2.1 2.5 2.5 2.5 2.5 1.6 2.1 1.0 2.1 2.5 2.2 2.5 1.7
# (UU) 2.3 1.2 0.6 1.2 1.7 1.7 1.7 1.7 0.7 1.2 1.4 1.2 1.7 1.4 1.7 0.8
# 5' ------> 3'
A X1 Y1 A
U X2 Y2 U
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G U U U U
A C G U A C G U A C G U A C G U
#----------------------------------------------------------------------------------------------------------------------------------
AA 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 1.8 2.3 1.2 2.3 2.8 2.5 2.8 2.5
AC 2.6 2.2 1.6 2.2 2.6 2.6 2.6 2.6 1.7 2.2 1.1 2.2 2.6 2.3 2.6 1.8
AG 2.2 1.8 1.2 1.8 2.2 2.8 2.2 2.8 1.3 1.8 2.0 1.8 2.2 2.5 2.2 1.4
AU 2.6 2.2 1.6 2.2 2.6 2.6 2.6 2.6 1.7 2.2 1.1 2.2 2.6 2.3 2.6 1.8
CA 2.5 2.1 1.5 2.1 2.5 2.5 2.5 2.5 1.6 2.1 1.0 2.1 2.5 2.2 2.5 1.7
CC 2.6 2.1 2.1 2.1 2.6 2.6 2.6 2.6 2.2 2.1 1.0 2.1 2.6 2.3 2.6 1.7
CG 2.5 2.1 1.5 2.1 2.5 2.5 2.5 2.5 1.6 2.1 1.0 2.1 2.5 2.2 2.5 1.7
CU 2.6 2.1 2.1 2.1 2.6 2.6 2.6 2.6 2.2 2.1 1.0 2.1 2.6 2.3 2.6 1.7
GA 1.5 1.1 0.5 1.1 1.5 2.1 1.5 2.1 0.6 1.1 1.3 1.1 1.5 1.8 1.5 0.7
GC 2.6 2.2 1.6 2.2 2.6 2.6 2.6 2.6 1.7 2.2 1.1 2.2 2.6 2.3 2.6 1.8
GG 1.0 0.6 1.3 0.6 1.0 1.0 1.0 1.0 1.4 0.6 2.1 0.6 1.0 0.7 1.0 1.5
GU 2.6 2.2 1.6 2.2 2.6 2.6 2.6 2.6 1.7 2.2 1.1 2.2 2.6 2.3 2.6 1.8
UA 2.5 2.1 1.5 2.1 2.5 2.5 2.5 2.5 1.6 2.1 1.0 2.1 2.5 2.2 2.5 1.7
UC 2.6 2.1 2.1 2.1 2.6 2.6 2.6 2.6 2.2 2.1 1.0 2.1 2.6 2.3 2.6 1.7
UG 2.5 2.1 1.5 2.1 2.5 2.5 2.5 2.5 1.6 2.1 1.0 2.1 2.5 2.2 2.5 1.7
UU 2.3 1.2 0.6 1.2 1.7 1.7 1.7 1.7 0.7 1.2 1.4 1.2 1.7 1.4 1.7 0.8
# 5' ------> 3'
A X1 Y1 C
U X2 Y2 G
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G U U U U
A C G U A C G U A C G U A C G U
#----------------------------------------------------------------------------------------------------------------------------------
AA 2.1 1.9 0.1 1.9 1.8 1.9 1.8 1.9 0.7 1.9 0.5 1.9 1.8 1.9 1.8 1.7
AC 2.0 1.7 0.0 1.7 1.7 1.7 1.7 1.7 0.6 1.7 0.3 1.7 1.7 1.8 1.7 1.0
AG 1.6 1.3 -0.4 1.3 1.3 1.9 1.3 1.9 0.2 1.3 1.2 1.3 1.3 2.0 1.3 0.6
AU 2.0 1.7 0.0 1.7 1.7 1.7 1.7 1.7 0.6 1.7 0.3 1.7 1.7 1.8 1.7 1.0
CA 1.9 1.6 -0.1 1.6 1.6 1.6 1.6 1.6 0.5 1.6 0.2 1.6 1.6 1.7 1.6 0.9
CC 1.9 1.7 0.5 1.7 1.6 1.7 1.6 1.7 1.1 1.7 0.3 1.7 1.6 1.7 1.6 0.9
CG 1.9 1.6 -0.1 1.6 1.6 1.6 1.6 1.6 0.5 1.6 0.2 1.6 1.6 1.7 1.6 0.9
CU 1.9 1.7 0.5 1.7 1.6 1.7 1.6 1.7 1.1 1.7 0.3 1.7 1.6 1.7 1.6 0.9
GA 0.9 0.6 -1.1 0.6 0.6 1.2 0.6 1.2 -0.5 0.6 0.5 0.6 0.6 1.3 0.6 -0.1
GC 2.0 1.7 0.0 1.7 1.7 1.7 1.7 1.7 0.6 1.7 0.3 1.7 1.7 1.8 1.7 1.0
GG 0.4 0.1 -0.3 0.1 0.1 0.1 0.1 0.1 0.3 0.1 1.3 0.1 0.1 0.2 0.1 0.7
GU 2.0 1.7 0.0 1.7 1.7 1.7 1.7 1.7 0.6 1.7 0.3 1.7 1.7 1.8 1.7 1.0
UA 1.9 1.6 -0.1 1.6 1.6 1.6 1.6 1.6 0.5 1.6 0.2 1.6 1.6 1.7 1.6 0.9
UC 1.9 1.7 0.5 1.7 1.6 1.7 1.6 1.7 1.1 1.7 0.3 1.7 1.6 1.7 1.6 0.9
UG 1.9 1.6 -0.1 1.6 1.6 1.6 1.6 1.6 0.5 1.6 0.2 1.6 1.6 1.7 1.6 0.9
UU 1.6 0.8 -1.0 0.8 0.7 0.8 0.7 0.8 -0.3 0.8 0.7 0.8 0.7 0.8 0.7 0.0
# 5' ------> 3'
A X1 Y1 G
U X2 Y2 C
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G U U U U
A C G U A C G U A C G U A C G U
#----------------------------------------------------------------------------------------------------------------------------------
AA 2.0 1.9 1.0 1.9 2.4 2.2 2.4 2.1 1.0 1.9 0.5 1.9 2.4 2.1 2.4 1.8
AC 1.8 1.8 0.9 1.8 2.2 2.1 2.2 1.9 0.9 1.8 0.3 1.8 2.2 1.9 2.2 1.0
AG 1.4 1.4 0.5 1.4 1.8 2.3 1.8 2.1 0.5 1.4 1.2 1.4 1.8 2.1 1.8 0.6
AU 1.8 1.8 0.9 1.8 2.2 2.1 2.2 1.9 0.9 1.8 0.3 1.8 2.2 1.9 2.2 1.0
CA 1.7 1.7 0.8 1.7 2.1 2.0 2.1 1.8 0.8 1.7 0.2 1.7 2.1 1.8 2.1 0.9
CC 1.8 1.7 1.4 1.7 2.2 2.0 2.2 1.9 1.4 1.7 0.3 1.7 2.2 1.9 2.2 1.0
CG 1.7 1.7 0.8 1.7 2.1 2.0 2.1 1.8 0.8 1.7 0.2 1.7 2.1 1.8 2.1 0.9
CU 1.8 1.7 1.4 1.7 2.2 2.0 2.2 1.9 1.4 1.7 0.3 1.7 2.2 1.9 2.2 1.0
GA 0.7 0.7 -0.2 0.7 1.1 1.6 1.1 1.4 -0.2 0.7 0.5 0.7 1.1 1.4 1.1 0.0
GC 1.8 1.8 0.9 1.8 2.2 2.1 2.2 1.9 0.9 1.8 0.3 1.8 2.2 1.9 2.2 1.0
GG 0.2 0.2 0.6 0.2 0.6 0.5 0.6 0.3 0.6 0.2 1.3 0.2 0.6 0.3 0.6 0.7
GU 1.8 1.8 0.9 1.8 2.2 2.1 2.2 1.9 0.9 1.8 0.3 1.8 2.2 1.9 2.2 1.0
UA 1.7 1.7 0.8 1.7 2.1 2.0 2.1 1.8 0.8 1.7 0.2 1.7 2.1 1.8 2.1 0.9
UC 1.8 1.7 1.4 1.7 2.2 2.0 2.2 1.9 1.4 1.7 0.3 1.7 2.2 1.9 2.2 1.0
UG 1.7 1.7 0.8 1.7 2.1 2.0 2.1 1.8 0.8 1.7 0.2 1.7 2.1 1.8 2.1 0.9
UU 1.5 0.8 0.0 0.8 1.3 1.1 1.3 1.0 0.0 0.8 0.7 0.8 1.3 1.0 1.3 0.1
# 5' ------> 3'
A X1 Y1 G
U X2 Y2 U
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G U U U U
A C G U A C G U A C G U A C G U
#----------------------------------------------------------------------------------------------------------------------------------
AA 2.4 2.8 1.4 2.8 2.8 2.8 2.8 2.8 3.1 2.8 1.5 2.8 2.8 2.8 2.8 3.4
AC 2.3 2.6 1.3 2.6 2.6 2.6 2.6 2.6 2.9 2.6 1.3 2.6 2.6 2.6 2.6 2.6
AG 1.9 2.2 0.9 2.2 2.2 2.8 2.2 2.8 2.5 2.2 2.2 2.2 2.2 2.8 2.2 2.2
AU 2.3 2.6 1.3 2.6 2.6 2.6 2.6 2.6 2.9 2.6 1.3 2.6 2.6 2.6 2.6 2.6
CA 2.2 2.5 1.2 2.5 2.5 2.5 2.5 2.5 2.8 2.5 1.2 2.5 2.5 2.5 2.5 2.5
CC 2.2 2.6 1.8 2.6 2.6 2.6 2.6 2.6 3.5 2.6 1.3 2.6 2.6 2.6 2.6 2.6
CG 2.2 2.5 1.2 2.5 2.5 2.5 2.5 2.5 2.8 2.5 1.2 2.5 2.5 2.5 2.5 2.5
CU 2.2 2.6 1.8 2.6 2.6 2.6 2.6 2.6 3.5 2.6 1.3 2.6 2.6 2.6 2.6 2.6
GA 1.2 1.5 0.2 1.5 1.5 2.1 1.5 2.1 1.8 1.5 1.5 1.5 1.5 2.1 1.5 1.5
GC 2.3 2.6 1.3 2.6 2.6 2.6 2.6 2.6 2.9 2.6 1.3 2.6 2.6 2.6 2.6 2.6
GG 0.7 1.0 1.0 1.0 1.0 1.0 1.0 1.0 2.6 1.0 2.3 1.0 1.0 1.0 1.0 2.3
GU 2.3 2.6 1.3 2.6 2.6 2.6 2.6 2.6 2.9 2.6 1.3 2.6 2.6 2.6 2.6 2.6
UA 2.2 2.5 1.2 2.5 2.5 2.5 2.5 2.5 2.8 2.5 1.2 2.5 2.5 2.5 2.5 2.5
UC 2.2 2.6 1.8 2.6 2.6 2.6 2.6 2.6 3.5 2.6 1.3 2.6 2.6 2.6 2.6 2.6
UG 2.2 2.5 1.2 2.5 2.5 2.5 2.5 2.5 2.8 2.5 1.2 2.5 2.5 2.5 2.5 2.5
UU 1.9 1.7 0.3 1.7 1.7 1.7 1.7 1.7 2.0 1.7 1.7 1.7 1.7 1.7 1.7 1.7
# 5' ------> 3'
A X1 Y1 U
U X2 Y2 A
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G U U U U
A C G U A C G U A C G U A C G U
#----------------------------------------------------------------------------------------------------------------------------------
AA 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.2 2.5 1.0 2.5 2.6 2.6 2.6 2.3
AC 2.6 2.4 1.4 2.4 2.5 2.4 2.5 2.4 2.1 2.4 0.9 2.4 2.5 2.4 2.5 1.5
AG 2.2 2.0 1.0 2.0 2.1 2.6 2.1 2.6 1.7 2.0 1.8 2.0 2.1 2.6 2.1 1.1
AU 2.6 2.4 1.4 2.4 2.5 2.4 2.5 2.4 2.1 2.4 0.9 2.4 2.5 2.4 2.5 1.5
CA 2.5 2.3 1.3 2.3 2.4 2.3 2.4 2.3 2.0 2.3 0.8 2.3 2.4 2.3 2.4 1.4
CC 2.6 2.3 1.9 2.3 2.4 2.4 2.4 2.4 2.6 2.3 0.8 2.3 2.4 2.4 2.4 1.5
CG 2.5 2.3 1.3 2.3 2.4 2.3 2.4 2.3 2.0 2.3 0.8 2.3 2.4 2.3 2.4 1.4
CU 2.6 2.3 1.9 2.3 2.4 2.4 2.4 2.4 2.6 2.3 0.8 2.3 2.4 2.4 2.4 1.5
GA 1.5 1.3 0.3 1.3 1.4 1.9 1.4 1.9 1.0 1.3 1.1 1.3 1.4 1.9 1.4 0.4
GC 2.6 2.4 1.4 2.4 2.5 2.4 2.5 2.4 2.1 2.4 0.9 2.4 2.5 2.4 2.5 1.5
GG 1.0 0.8 1.1 0.8 0.9 0.8 0.9 0.8 1.8 0.8 1.9 0.8 0.9 0.8 0.9 1.2
GU 2.6 2.4 1.4 2.4 2.5 2.4 2.5 2.4 2.1 2.4 0.9 2.4 2.5 2.4 2.5 1.5
UA 2.5 2.3 1.3 2.3 2.4 2.3 2.4 2.3 2.0 2.3 0.8 2.3 2.4 2.3 2.4 1.4
UC 2.6 2.3 1.9 2.3 2.4 2.4 2.4 2.4 2.6 2.3 0.8 2.3 2.4 2.4 2.4 1.5
UG 2.5 2.3 1.3 2.3 2.4 2.3 2.4 2.3 2.0 2.3 0.8 2.3 2.4 2.3 2.4 1.4
UU 2.3 1.4 0.4 1.4 1.5 1.5 1.5 1.5 1.1 1.4 1.2 1.4 1.5 1.5 1.5 0.6
# 5' ------> 3'
A X1 Y1 U
U X2 Y2 G
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G U U U U
A C G U A C G U A C G U A C G U
#----------------------------------------------------------------------------------------------------------------------------------
AA 3.4 3.1 2.3 3.1 3.1 3.1 3.1 3.1 2.7 3.1 1.8 3.1 3.1 3.1 3.1 3.7
AC 3.3 2.9 2.1 2.9 2.9 2.9 2.9 2.9 2.5 2.9 1.6 2.9 2.9 2.9 2.9 2.9
AG 2.9 2.5 1.7 2.5 2.5 3.1 2.5 3.1 2.1 2.5 2.5 2.5 2.5 3.1 2.5 2.5
AU 3.3 2.9 2.1 2.9 2.9 2.9 2.9 2.9 2.5 2.9 1.6 2.9 2.9 2.9 2.9 2.9
CA 3.2 2.8 2.0 2.8 2.8 2.8 2.8 2.8 2.4 2.8 1.5 2.8 2.8 2.8 2.8 2.8
CC 3.2 2.9 2.7 2.9 2.9 2.9 2.9 2.9 3.1 2.9 1.6 2.9 2.9 2.9 2.9 2.9
CG 3.2 2.8 2.0 2.8 2.8 2.8 2.8 2.8 2.4 2.8 1.5 2.8 2.8 2.8 2.8 2.8
CU 3.2 2.9 2.7 2.9 2.9 2.9 2.9 2.9 3.1 2.9 1.6 2.9 2.9 2.9 2.9 2.9
GA 2.2 1.8 1.0 1.8 1.8 2.4 1.8 2.4 1.4 1.8 1.8 1.8 1.8 2.4 1.8 1.8
GC 3.3 2.9 2.1 2.9 2.9 2.9 2.9 2.9 2.5 2.9 1.6 2.9 2.9 2.9 2.9 2.9
GG 1.7 1.3 1.8 1.3 1.3 1.3 1.3 1.3 2.2 1.3 2.6 1.3 1.3 1.3 1.3 2.6
GU 3.3 2.9 2.1 2.9 2.9 2.9 2.9 2.9 2.5 2.9 1.6 2.9 2.9 2.9 2.9 2.9
UA 3.2 2.8 2.0 2.8 2.8 2.8 2.8 2.8 2.4 2.8 1.5 2.8 2.8 2.8 2.8 2.8
UC 3.2 2.9 2.7 2.9 2.9 2.9 2.9 2.9 3.1 2.9 1.6 2.9 2.9 2.9 2.9 2.9
UG 3.2 2.8 2.0 2.8 2.8 2.8 2.8 2.8 2.4 2.8 1.5 2.8 2.8 2.8 2.8 2.8
UU 2.9 2.0 1.2 2.0 2.0 2.0 2.0 2.0 1.6 2.0 2.0 2.0 2.0 2.0 2.0 2.0
# 5' ------> 3'
C X1 Y1 A
G X2 Y2 U
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G U U U U
A C G U A C G U A C G U A C G U
#----------------------------------------------------------------------------------------------------------------------------------
AA 2.0 1.5 0.9 1.5 2.0 2.0 2.0 2.0 1.0 1.5 0.4 1.5 2.0 1.7 2.0 1.7
AC 2.4 1.9 1.3 1.9 2.4 2.4 2.4 2.4 1.4 1.9 0.8 1.9 2.4 2.1 2.4 1.5
AG 1.0 0.6 0.0 0.6 1.0 1.6 1.0 1.6 0.1 0.6 0.8 0.6 1.0 1.3 1.0 0.2
AU 2.4 1.9 1.3 1.9 2.4 2.4 2.4 2.4 1.4 1.9 0.8 1.9 2.4 2.1 2.4 1.5
CA 1.9 1.5 0.9 1.5 1.9 1.9 1.9 1.9 1.0 1.5 0.4 1.5 1.9 1.6 1.9 1.1
CC 2.2 1.8 1.8 1.8 2.2 2.2 2.2 2.2 1.9 1.8 0.7 1.8 2.2 1.9 2.2 1.4
CG 1.9 1.5 0.9 1.5 1.9 1.9 1.9 1.9 1.0 1.5 0.4 1.5 1.9 1.6 1.9 1.1
CU 2.1 1.6 1.6 1.6 2.1 2.1 2.1 2.1 1.7 1.6 0.5 1.6 2.1 1.8 2.1 1.2
GA 1.0 0.6 0.0 0.6 1.0 1.6 1.0 1.6 0.1 0.6 0.8 0.6 1.0 1.3 1.0 0.2
GC 2.4 1.9 1.3 1.9 2.4 2.4 2.4 2.4 1.4 1.9 0.8 1.9 2.4 2.1 2.4 1.5
GG 0.5 0.0 0.7 0.0 0.5 0.5 0.5 0.5 0.8 0.0 1.5 0.0 0.5 0.2 0.5 0.9
GU 2.4 1.9 1.3 1.9 2.4 2.4 2.4 2.4 1.4 1.9 0.8 1.9 2.4 2.1 2.4 1.5
UA 1.9 1.5 0.9 1.5 1.9 1.9 1.9 1.9 1.0 1.5 0.4 1.5 1.9 1.6 1.9 1.1
UC 2.1 1.6 1.6 1.6 2.1 2.1 2.1 2.1 1.7 1.6 0.5 1.6 2.1 1.8 2.1 1.2
UG 1.9 1.5 0.9 1.5 1.9 1.9 1.9 1.9 1.0 1.5 0.4 1.5 1.9 1.6 1.9 1.1
UU 1.8 0.7 0.1 0.7 1.2 1.2 1.2 1.2 0.2 0.7 0.9 0.7 1.2 0.9 1.2 0.3
# 5' ------> 3'
C X1 Y1 C
G X2 Y2 G
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G U U U U
A C G U A C G U A C G U A C G U
#----------------------------------------------------------------------------------------------------------------------------------
AA 1.3 1.1 -0.3 1.1 1.0 1.1 1.0 1.1 0.4 1.1 -0.3 1.1 1.0 1.1 1.0 1.5
AC 0.6 1.5 0.1 1.5 0.5 1.5 1.4 1.5 0.3 1.5 -0.3 1.5 1.4 1.5 1.4 0.0
AG 0.0 -0.7 -1.6 0.1 -1.0 -0.6 0.1 0.7 -0.7 0.1 0.0 0.1 0.1 0.8 0.1 0.9
AU 1.7 1.5 -0.3 1.5 1.4 1.5 1.4 1.5 0.3 1.5 0.1 1.5 1.4 1.5 1.4 0.7
CA 1.3 1.0 -0.7 1.0 1.1 1.0 1.0 1.0 0.7 1.0 -0.4 1.0 1.0 1.1 1.0 -0.2
CC 2.2 1.3 0.7 1.3 1.9 1.3 1.3 1.3 0.7 1.3 -0.1 1.3 1.3 1.4 1.3 -0.1
CG 1.3 1.0 -0.7 1.0 1.0 1.0 1.0 1.0 -0.1 1.0 -0.4 1.0 1.0 1.1 1.0 0.3
CU 1.4 1.2 0.0 1.2 1.1 1.2 1.1 1.7 0.6 1.2 0.2 1.2 1.1 1.2 1.1 0.2
GA -0.2 -0.4 -1.7 0.1 0.7 0.7 0.1 0.7 -0.5 0.1 -0.3 0.1 0.1 0.8 0.1 0.9
GC 1.7 1.5 -0.3 1.5 1.4 1.5 1.4 1.5 0.3 1.5 0.1 1.5 1.4 1.5 1.4 0.7
GG -0.1 -0.4 -0.9 -0.4 -0.5 -0.4 -0.5 0.2 -0.3 -0.4 0.8 -0.4 -0.5 -0.5 -0.5 1.4
GU 1.7 1.5 -0.3 1.5 1.4 1.5 1.4 1.5 0.3 1.5 0.1 1.5 1.4 1.5 1.4 0.7
UA 1.3 1.0 -0.7 1.0 1.0 1.0 1.0 1.0 -0.1 1.0 -0.4 1.0 1.0 1.1 1.0 0.3
UC 1.4 1.2 0.0 1.2 1.1 1.2 1.1 1.2 0.5 1.2 -0.6 1.2 1.1 1.2 1.1 0.4
UG 1.3 1.0 -0.7 1.0 1.0 1.0 1.0 1.0 -0.1 1.0 -0.4 1.0 1.0 1.1 1.0 0.3
UU 1.4 0.3 0.5 0.3 0.3 0.3 0.2 0.3 1.4 0.3 0.7 0.3 0.2 0.3 0.2 -0.6
# 5' ------> 3'
C X1 Y1 G
G X2 Y2 C
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G U U U U
A C G U A C G U A C G U A C G U
#----------------------------------------------------------------------------------------------------------------------------------
AA 1.2 1.1 0.2 1.1 1.6 1.4 1.6 1.3 0.2 1.1 -0.3 1.1 1.6 1.3 1.6 1.0
AC 1.6 1.5 0.6 1.5 2.0 1.8 2.0 1.7 0.6 1.5 0.1 1.5 2.0 1.7 2.0 0.8
AG 0.2 0.2 -0.7 0.2 0.6 1.1 0.6 0.9 -0.7 0.2 0.0 0.2 0.6 0.9 0.6 -0.5
AU 1.6 1.5 0.6 1.5 2.0 1.8 2.0 1.7 0.6 1.5 0.1 1.5 2.0 1.7 2.0 0.8
CA 1.1 1.1 0.2 1.1 1.5 1.4 1.5 1.2 0.2 1.1 -0.4 1.1 1.5 1.2 1.5 0.3
CC 1.4 1.4 1.1 1.4 1.8 1.7 1.8 1.5 1.1 1.4 -0.1 1.4 1.8 1.5 1.8 0.6
CG 1.1 1.1 0.2 1.1 1.5 1.4 1.5 1.2 0.2 1.1 -0.4 1.1 1.5 1.2 1.5 0.3
CU 1.3 1.2 0.9 1.2 1.7 1.5 1.7 1.4 0.9 1.2 -0.2 1.2 1.7 1.4 1.7 0.5
GA 0.2 0.2 -0.7 0.2 0.6 1.1 0.6 0.9 -0.7 0.2 0.0 0.2 0.6 0.9 0.6 -0.5
GC 1.6 1.5 0.6 1.5 2.0 1.8 2.0 1.7 0.6 1.5 0.1 1.5 2.0 1.7 2.0 0.8
GG -0.3 -0.4 0.0 -0.4 0.1 -0.1 0.1 -0.2 0.0 -0.4 0.8 -0.4 0.1 -0.2 0.1 0.2
GU 1.6 1.5 0.6 1.5 2.0 1.8 2.0 1.7 0.6 1.5 0.1 1.5 2.0 1.7 2.0 0.8
UA 1.1 1.1 0.2 1.1 1.5 1.4 1.5 1.2 0.2 1.1 -0.4 1.1 1.5 1.2 1.5 0.3
UC 1.3 1.2 0.9 1.2 1.7 1.5 1.7 1.4 0.9 1.2 -0.2 1.2 1.7 1.4 1.7 0.5
UG 1.1 1.1 0.2 1.1 1.5 1.4 1.5 1.2 0.2 1.1 -0.4 1.1 1.5 1.2 1.5 0.3
UU 1.0 0.3 -0.5 0.3 0.8 0.6 0.8 0.5 -0.5 0.3 0.2 0.3 0.8 0.5 0.8 -0.4
# 5' ------> 3'
C X1 Y1 G
G X2 Y2 U
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G U U U U
A C G U A C G U A C G U A C G U
#----------------------------------------------------------------------------------------------------------------------------------
AA 1.6 2.0 0.6 2.0 2.0 2.0 2.0 2.0 2.3 2.0 0.7 2.0 2.0 2.0 2.0 2.6
AC 2.0 2.4 1.0 2.4 2.4 2.4 2.4 2.4 2.7 2.4 1.1 2.4 2.4 2.4 2.4 2.4
AG 0.7 1.0 -0.3 1.0 1.0 1.6 1.0 1.6 1.3 1.0 1.0 1.0 1.0 1.6 1.0 1.0
AU 2.0 2.4 1.0 2.4 2.4 2.4 2.4 2.4 2.7 2.4 1.1 2.4 2.4 2.4 2.4 2.4
CA 1.6 1.9 0.6 1.9 1.9 1.9 1.9 1.9 2.2 1.9 0.6 1.9 1.9 1.9 1.9 1.9
CC 1.9 2.2 1.5 2.2 2.2 2.2 2.2 2.2 3.1 2.2 0.9 2.2 2.2 2.2 2.2 2.2
CG 1.6 1.9 0.6 1.9 1.9 1.9 1.9 1.9 2.2 1.9 0.6 1.9 1.9 1.9 1.9 1.9
CU 1.7 2.1 1.3 2.1 2.1 2.1 2.1 2.1 3.0 2.1 0.8 2.1 2.1 2.1 2.1 2.1
GA 0.7 1.0 -0.3 1.0 1.0 1.6 1.0 1.6 1.3 1.0 1.0 1.0 1.0 1.6 1.0 1.0
GC 2.0 2.4 1.0 2.4 2.4 2.4 2.4 2.4 2.7 2.4 1.1 2.4 2.4 2.4 2.4 2.4
GG 0.1 0.5 0.4 0.5 0.5 0.5 0.5 0.5 2.1 0.5 1.8 0.5 0.5 0.5 0.5 1.8
GU 2.0 2.4 1.0 2.4 2.4 2.4 2.4 2.4 2.7 2.4 1.1 2.4 2.4 2.4 2.4 2.4
UA 1.6 1.9 0.6 1.9 1.9 1.9 1.9 1.9 2.2 1.9 0.6 1.9 1.9 1.9 1.9 1.9
UC 1.7 2.1 1.3 2.1 2.1 2.1 2.1 2.1 3.0 2.1 0.8 2.1 2.1 2.1 2.1 2.1
UG 1.6 1.9 0.6 1.9 1.9 1.9 1.9 1.9 2.2 1.9 0.6 1.9 1.9 1.9 1.9 1.9
UU 1.4 1.2 -0.1 1.2 1.2 1.2 1.2 1.2 1.5 1.2 1.2 1.2 1.2 1.2 1.2 1.2
# 5' ------> 3'
C X1 Y1 U
G X2 Y2 A
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G U U U U
A C G U A C G U A C G U A C G U
#----------------------------------------------------------------------------------------------------------------------------------
AA 2.0 1.7 0.7 1.7 1.8 1.8 1.8 1.8 1.4 1.7 0.2 1.7 1.8 1.8 1.8 1.5
AC 2.4 2.1 1.1 2.1 2.2 2.2 2.2 2.2 1.8 2.1 0.6 2.1 2.2 2.2 2.2 1.3
AG 1.0 0.8 -0.2 0.8 0.9 1.4 0.9 1.4 0.5 0.8 0.6 0.8 0.9 1.4 0.9 0.0
AU 2.4 2.1 1.1 2.1 2.2 2.2 2.2 2.2 1.8 2.1 0.6 2.1 2.2 2.2 2.2 1.3
CA 1.9 1.7 0.7 1.7 1.8 1.7 1.8 1.7 1.4 1.7 0.2 1.7 1.8 1.7 1.8 0.8
CC 2.2 2.0 1.6 2.0 2.1 2.0 2.1 2.0 2.3 2.0 0.5 2.0 2.1 2.0 2.1 1.1
CG 1.9 1.7 0.7 1.7 1.8 1.7 1.8 1.7 1.4 1.7 0.2 1.7 1.8 1.7 1.8 0.8
CU 2.1 1.8 1.4 1.8 1.9 1.9 1.9 1.9 2.1 1.8 0.3 1.8 1.9 1.9 1.9 1.0
GA 1.0 0.8 -0.2 0.8 0.9 1.4 0.9 1.4 0.5 0.8 0.6 0.8 0.9 1.4 0.9 0.0
GC 2.4 2.1 1.1 2.1 2.2 2.2 2.2 2.2 1.8 2.1 0.6 2.1 2.2 2.2 2.2 1.3
GG 0.5 0.2 0.5 0.2 0.3 0.3 0.3 0.3 1.2 0.2 1.3 0.2 0.3 0.3 0.3 0.7
GU 2.4 2.1 1.1 2.1 2.2 2.2 2.2 2.2 1.8 2.1 0.6 2.1 2.2 2.2 2.2 1.3
UA 1.9 1.7 0.7 1.7 1.8 1.7 1.8 1.7 1.4 1.7 0.2 1.7 1.8 1.7 1.8 0.8
UC 2.1 1.8 1.4 1.8 1.9 1.9 1.9 1.9 2.1 1.8 0.3 1.8 1.9 1.9 1.9 1.0
UG 1.9 1.7 0.7 1.7 1.8 1.7 1.8 1.7 1.4 1.7 0.2 1.7 1.8 1.7 1.8 0.8
UU 1.8 0.9 0.0 0.9 1.0 1.0 1.0 1.0 0.6 0.9 0.7 0.9 1.0 1.0 1.0 0.1
# 5' ------> 3'
C X1 Y1 U
G X2 Y2 G
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G U U U U
A C G U A C G U A C G U A C G U
#----------------------------------------------------------------------------------------------------------------------------------
AA 2.7 2.3 1.5 2.3 2.3 2.3 2.3 2.3 1.9 2.3 1.0 2.3 2.3 2.3 2.3 2.9
AC 3.0 2.7 1.9 2.7 2.7 2.7 2.7 2.7 2.3 2.7 1.4 2.7 2.7 2.7 2.7 2.7
AG 1.7 1.3 0.5 1.3 1.3 1.9 1.3 1.9 0.9 1.3 1.3 1.3 1.3 1.9 1.3 1.3
AU 3.0 2.7 1.9 2.7 2.7 2.7 2.7 2.7 2.3 2.7 1.4 2.7 2.7 2.7 2.7 2.7
CA 2.6 2.2 1.4 2.2 2.2 2.2 2.2 2.2 1.8 2.2 0.9 2.2 2.2 2.2 2.2 2.2
CC 2.9 2.5 2.3 2.5 2.5 2.5 2.5 2.5 2.7 2.5 1.2 2.5 2.5 2.5 2.5 2.5
CG 2.6 2.2 1.4 2.2 2.2 2.2 2.2 2.2 1.8 2.2 0.9 2.2 2.2 2.2 2.2 2.2
CU 2.7 2.4 2.2 2.4 2.4 2.4 2.4 2.4 2.6 2.4 1.1 2.4 2.4 2.4 2.4 2.4
GA 1.7 1.3 0.5 1.3 1.3 1.9 1.3 1.9 0.9 1.3 1.3 1.3 1.3 1.9 1.3 1.3
GC 3.0 2.7 1.9 2.7 2.7 2.7 2.7 2.7 2.3 2.7 1.4 2.7 2.7 2.7 2.7 2.7
GG 1.1 0.8 1.3 0.8 0.8 0.8 0.8 0.8 1.7 0.8 2.1 0.8 0.8 0.8 0.8 2.1
GU 3.0 2.7 1.9 2.7 2.7 2.7 2.7 2.7 2.3 2.7 1.4 2.7 2.7 2.7 2.7 2.7
UA 2.6 2.2 1.4 2.2 2.2 2.2 2.2 2.2 1.8 2.2 0.9 2.2 2.2 2.2 2.2 2.2
UC 2.7 2.4 2.2 2.4 2.4 2.4 2.4 2.4 2.6 2.4 1.1 2.4 2.4 2.4 2.4 2.4
UG 2.6 2.2 1.4 2.2 2.2 2.2 2.2 2.2 1.8 2.2 0.9 2.2 2.2 2.2 2.2 2.2
UU 2.4 1.5 0.7 1.5 1.5 1.5 1.5 1.5 1.1 1.5 1.5 1.5 1.5 1.5 1.5 1.5
# 5' ------> 3'
G X1 Y1 A
C X2 Y2 U
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G U U U U
A C G U A C G U A C G U A C G U
#----------------------------------------------------------------------------------------------------------------------------------
AA 2.1 1.7 1.1 1.7 2.1 2.1 2.1 2.1 1.2 1.7 0.6 1.7 2.1 1.8 2.1 1.9
AC 1.8 1.4 0.8 1.4 1.8 1.8 1.8 1.8 0.9 1.4 0.3 1.4 1.8 1.5 1.8 1.0
AG 0.7 0.3 -0.3 0.3 0.7 1.3 0.7 1.3 -0.2 0.3 0.5 0.3 0.7 1.0 0.7 -0.1
AU 1.8 1.4 0.8 1.4 1.8 1.8 1.8 1.8 0.9 1.4 0.3 1.4 1.8 1.5 1.8 1.0
CA 1.9 1.4 0.8 1.4 1.9 1.9 1.9 1.9 0.9 1.4 0.3 1.4 1.9 1.6 1.9 1.0
CC 1.9 1.4 1.4 1.4 1.9 1.9 1.9 1.9 1.5 1.4 0.3 1.4 1.9 1.6 1.9 1.0
CG 1.9 1.4 0.8 1.4 1.9 1.9 1.9 1.9 0.9 1.4 0.3 1.4 1.9 1.6 1.9 1.0
CU 1.9 1.5 1.5 1.5 1.9 1.9 1.9 1.9 1.6 1.5 0.4 1.5 1.9 1.6 1.9 1.1
GA 0.1 -0.3 -0.9 -0.3 0.1 0.7 0.1 0.7 -0.8 -0.3 -0.1 -0.3 0.1 0.4 0.1 -0.7
GC 1.8 1.4 0.8 1.4 1.8 1.8 1.8 1.8 0.9 1.4 0.3 1.4 1.8 1.5 1.8 1.0
GG 0.5 0.0 0.7 0.0 0.5 0.5 0.5 0.5 0.8 0.0 1.5 0.0 0.5 0.2 0.5 0.9
GU 1.8 1.4 0.8 1.4 1.8 1.8 1.8 1.8 0.9 1.4 0.3 1.4 1.8 1.5 1.8 1.0
UA 1.9 1.4 0.8 1.4 1.9 1.9 1.9 1.9 0.9 1.4 0.3 1.4 1.9 1.6 1.9 1.0
UC 1.9 1.4 1.4 1.4 1.9 1.9 1.9 1.9 1.5 1.4 0.3 1.4 1.9 1.6 1.9 1.0
UG 1.9 1.4 0.8 1.4 1.9 1.9 1.9 1.9 0.9 1.4 0.3 1.4 1.9 1.6 1.9 1.0
UU 1.7 0.7 0.1 0.7 1.1 1.1 1.1 1.1 0.2 0.7 0.9 0.7 1.1 0.8 1.1 0.3
# 5' ------> 3'
G X1 Y1 C
C X2 Y2 G
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G U U U U
A C G U A C G U A C G U A C G U
#----------------------------------------------------------------------------------------------------------------------------------
AA 1.5 1.2 -0.5 1.2 1.2 1.2 1.2 1.2 0.1 1.2 -0.2 1.2 1.2 1.3 1.2 1.1
AC 1.2 0.9 -0.8 0.9 0.9 0.9 0.9 0.9 -0.2 0.9 -0.5 0.9 0.9 1.0 0.9 0.2
AG 0.1 -0.1 -1.9 -0.1 -0.2 0.5 -0.2 0.5 -1.3 -0.1 -0.2 -0.1 -0.2 0.5 -0.2 -0.9
AU 1.2 0.9 -0.8 0.9 0.9 0.9 0.9 0.9 -0.2 0.9 -0.5 0.9 0.9 1.0 0.9 0.2
CA 1.2 1.0 -0.8 1.0 0.9 1.0 0.9 1.0 -0.1 1.0 -0.4 1.0 0.9 1.0 0.9 0.2
CC 1.2 1.0 -0.2 1.0 0.9 1.0 0.9 1.0 0.5 1.0 -0.4 1.0 0.9 1.0 0.9 0.2
CG 1.2 1.0 -0.8 1.0 0.9 1.0 0.9 1.0 -0.1 1.0 -0.4 1.0 0.9 1.0 0.9 0.2
CU 1.3 1.0 -0.1 1.0 1.0 1.0 1.0 1.0 0.5 1.0 -0.4 1.0 1.0 1.1 1.0 0.3
GA -0.5 -0.8 -2.6 -0.8 -0.8 -0.2 -0.8 -0.2 -1.9 -0.8 -0.9 -0.8 -0.8 -0.1 -0.8 -1.5
GC 1.2 0.9 -0.8 0.9 0.9 0.9 0.9 0.9 -0.2 0.9 -0.5 0.9 0.9 1.0 0.9 0.2
GG -0.2 -0.4 -0.9 -0.4 -0.5 -0.4 -0.5 -0.4 -0.2 -0.4 0.8 -0.4 -0.5 -0.4 -0.5 0.1
GU 1.2 0.9 -0.8 0.9 0.9 0.9 0.9 0.9 -0.2 0.9 -0.5 0.9 0.9 1.0 0.9 0.2
UA 1.2 1.0 -0.8 1.0 0.9 1.0 0.9 1.0 -0.1 1.0 -0.4 1.0 0.9 1.0 0.9 0.2
UC 1.2 1.0 -0.2 1.0 0.9 1.0 0.9 1.0 0.5 1.0 -0.4 1.0 0.9 1.0 0.9 0.2
UG 1.2 1.0 -0.8 1.0 0.9 1.0 0.9 1.0 -0.1 1.0 -0.4 1.0 0.9 1.0 0.9 0.2
UU 1.1 0.2 -1.5 0.2 0.2 0.2 0.2 0.2 -0.9 0.2 0.1 0.2 0.2 0.3 0.2 -0.5
# 5' ------> 3'
G X1 Y1 G
C X2 Y2 C
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G U U U U
A C G U A C G U A C G U A C G U
#----------------------------------------------------------------------------------------------------------------------------------
AA 1.3 1.3 -0.2 1.3 0.6 2.2 1.7 1.4 0.0 1.3 -0.1 1.3 1.7 1.4 1.7 1.4
AC 1.0 1.1 0.7 1.0 0.5 1.9 1.4 1.1 -1.0 1.0 -0.5 1.0 1.4 1.1 1.4 0.3
AG 0.4 0.7 -0.5 -0.1 0.3 0.7 0.3 0.5 -0.7 -0.1 -0.3 -0.1 0.3 0.6 0.3 1.4
AU 1.0 1.0 0.1 1.0 1.4 1.3 1.4 1.1 0.1 1.0 -0.5 1.0 1.4 1.1 1.4 0.2
CA 1.1 1.0 -0.4 1.0 1.5 1.3 1.5 1.2 -0.7 1.0 -0.4 1.0 1.5 1.2 1.5 0.3
CC 1.1 1.0 0.7 1.0 1.5 1.3 1.5 1.2 -0.6 1.0 -0.4 1.0 1.5 1.2 1.5 0.3
CG 1.1 1.0 0.1 1.0 1.5 1.3 1.5 1.2 0.1 1.0 -0.4 1.0 1.5 1.2 1.5 0.3
CU 1.1 1.1 0.8 1.1 1.5 1.4 1.5 1.2 0.8 1.1 -0.5 1.1 1.5 1.2 1.5 0.3
GA -0.3 -0.7 -1.7 -0.7 0.1 0.7 -0.3 0.0 -1.6 -0.7 -0.9 -0.7 -0.3 0.0 -0.3 0.5
GC 1.0 1.0 0.1 1.0 1.4 1.3 1.4 1.1 0.1 1.0 -0.5 1.0 1.4 1.1 1.4 0.2
GG -0.3 -0.4 -0.3 -0.4 -0.3 -0.1 0.1 -0.6 0.0 -0.4 0.8 -0.4 0.1 0.2 0.1 0.7
GU 1.0 1.0 0.1 1.0 1.4 1.3 1.4 1.1 0.1 1.0 -0.5 1.0 1.4 1.1 1.4 0.2
UA 1.1 1.0 0.1 1.0 1.5 1.3 1.5 1.2 0.1 1.0 -0.4 1.0 1.5 1.2 1.5 0.3
UC 1.1 1.0 0.7 1.0 1.5 1.3 1.5 1.2 0.7 1.0 0.2 1.0 1.5 1.7 1.5 0.3
UG 1.1 1.0 0.1 1.0 1.5 1.3 1.5 1.2 0.1 1.0 -0.4 1.0 1.5 1.2 1.5 0.3
UU 1.5 -0.2 0.9 0.3 0.0 -0.1 0.7 0.4 0.9 0.3 1.4 0.3 0.7 0.2 0.7 -0.6
# 5' ------> 3'
G X1 Y1 G
C X2 Y2 U
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G U U U U
A C G U A C G U A C G U A C G U
#----------------------------------------------------------------------------------------------------------------------------------
AA 1.9 2.1 0.8 2.1 2.1 2.1 2.1 2.1 2.4 2.1 0.8 2.1 2.1 2.1 2.1 2.7
AC 1.5 1.8 0.5 1.8 1.8 1.8 1.8 1.8 2.1 1.8 0.5 1.8 1.8 1.8 1.8 1.8
AG 0.4 0.7 -0.6 0.7 0.7 1.3 0.7 1.3 1.0 0.7 0.7 0.7 0.7 1.3 0.7 0.7
AU 1.5 1.8 0.5 1.8 1.8 1.8 1.8 1.8 2.1 1.8 0.5 1.8 1.8 1.8 1.8 1.8
CA 1.5 1.9 0.5 1.9 1.9 1.9 1.9 1.9 2.2 1.9 0.6 1.9 1.9 1.9 1.9 1.9
CC 1.5 1.9 1.1 1.9 1.9 1.9 1.9 1.9 2.8 1.9 0.6 1.9 1.9 1.9 1.9 1.9
CG 1.5 1.9 0.5 1.9 1.9 1.9 1.9 1.9 2.2 1.9 0.6 1.9 1.9 1.9 1.9 1.9
CU 1.6 1.9 1.2 1.9 1.9 1.9 1.9 1.9 2.8 1.9 0.6 1.9 1.9 1.9 1.9 1.9
GA -0.2 0.1 -1.2 0.1 0.1 0.7 0.1 0.7 0.4 0.1 0.1 0.1 0.1 0.7 0.1 0.1
GC 1.5 1.8 0.5 1.8 1.8 1.8 1.8 1.8 2.1 1.8 0.5 1.8 1.8 1.8 1.8 1.8
GG 0.1 0.5 0.4 0.5 0.5 0.5 0.5 0.5 2.1 0.5 1.8 0.5 0.5 0.5 0.5 1.8
GU 1.5 1.8 0.5 1.8 1.8 1.8 1.8 1.8 2.1 1.8 0.5 1.8 1.8 1.8 1.8 1.8
UA 1.5 1.9 0.5 1.9 1.9 1.9 1.9 1.9 2.2 1.9 0.6 1.9 1.9 1.9 1.9 1.9
UC 1.5 1.9 1.1 1.9 1.9 1.9 1.9 1.9 2.8 1.9 0.6 1.9 1.9 1.9 1.9 1.9
UG 1.5 1.9 0.5 1.9 1.9 1.9 1.9 1.9 2.2 1.9 0.6 1.9 1.9 1.9 1.9 1.9
UU 1.4 1.1 -0.2 1.1 1.1 1.1 1.1 1.1 1.4 1.1 1.1 1.1 1.1 1.1 1.1 1.1
# 5' ------> 3'
G X1 Y1 U
C X2 Y2 A
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G U U U U
A C G U A C G U A C G U A C G U
#----------------------------------------------------------------------------------------------------------------------------------
AA 2.1 1.9 0.9 1.9 2.0 1.9 2.0 1.9 1.6 1.9 0.4 1.9 2.0 1.9 2.0 1.6
AC 1.8 1.6 0.6 1.6 1.7 1.6 1.7 1.6 1.3 1.6 0.1 1.6 1.7 1.6 1.7 0.7
AG 0.7 0.5 -0.5 0.5 0.6 1.1 0.6 1.1 0.2 0.5 0.3 0.5 0.6 1.1 0.6 -0.3
AU 1.8 1.6 0.6 1.6 1.7 1.6 1.7 1.6 1.3 1.6 0.1 1.6 1.7 1.6 1.7 0.7
CA 1.9 1.6 0.6 1.6 1.7 1.7 1.7 1.7 1.3 1.6 0.1 1.6 1.7 1.7 1.7 0.8
CC 1.9 1.6 1.2 1.6 1.7 1.7 1.7 1.7 1.9 1.6 0.1 1.6 1.7 1.7 1.7 0.8
CG 1.9 1.6 0.6 1.6 1.7 1.7 1.7 1.7 1.3 1.6 0.1 1.6 1.7 1.7 1.7 0.8
CU 1.9 1.7 1.3 1.7 1.8 1.7 1.8 1.7 2.0 1.7 0.2 1.7 1.8 1.7 1.8 0.8
GA 0.1 -0.1 -1.1 -0.1 0.0 0.5 0.0 0.5 -0.4 -0.1 -0.3 -0.1 0.0 0.5 0.0 -1.0
GC 1.8 1.6 0.6 1.6 1.7 1.6 1.7 1.6 1.3 1.6 0.1 1.6 1.7 1.6 1.7 0.7
GG 0.5 0.2 0.5 0.2 0.3 0.3 0.3 0.3 1.2 0.2 1.3 0.2 0.3 0.3 0.3 0.7
GU 1.8 1.6 0.6 1.6 1.7 1.6 1.7 1.6 1.3 1.6 0.1 1.6 1.7 1.6 1.7 0.7
UA 1.9 1.6 0.6 1.6 1.7 1.7 1.7 1.7 1.3 1.6 0.1 1.6 1.7 1.7 1.7 0.8
UC 1.9 1.6 1.2 1.6 1.7 1.7 1.7 1.7 1.9 1.6 0.1 1.6 1.7 1.7 1.7 0.8
UG 1.9 1.6 0.6 1.6 1.7 1.7 1.7 1.7 1.3 1.6 0.1 1.6 1.7 1.7 1.7 0.8
UU 1.7 0.9 -0.1 0.9 1.0 0.9 1.0 0.9 0.6 0.9 0.7 0.9 1.0 0.9 1.0 0.0
# 5' ------> 3'
G X1 Y1 U
C X2 Y2 G
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G U U U U
A C G U A C G U A C G U A C G U
#----------------------------------------------------------------------------------------------------------------------------------
AA 2.8 2.4 1.6 2.4 2.4 2.4 2.4 2.4 2.0 2.4 1.1 2.4 2.4 2.4 2.4 3.0
AC 2.5 2.1 1.3 2.1 2.1 2.1 2.1 2.1 1.7 2.1 0.8 2.1 2.1 2.1 2.1 2.1
AG 1.4 1.0 0.2 1.0 1.0 1.6 1.0 1.6 0.6 1.0 1.0 1.0 1.0 1.6 1.0 1.0
AU 2.5 2.1 1.3 2.1 2.1 2.1 2.1 2.1 1.7 2.1 0.8 2.1 2.1 2.1 2.1 2.1
CA 2.5 2.2 1.4 2.2 2.2 2.2 2.2 2.2 1.8 2.2 0.9 2.2 2.2 2.2 2.2 2.2
CC 2.5 2.2 2.0 2.2 2.2 2.2 2.2 2.2 2.4 2.2 0.9 2.2 2.2 2.2 2.2 2.2
CG 2.5 2.2 1.4 2.2 2.2 2.2 2.2 2.2 1.8 2.2 0.9 2.2 2.2 2.2 2.2 2.2
CU 2.6 2.2 2.0 2.2 2.2 2.2 2.2 2.2 2.4 2.2 0.9 2.2 2.2 2.2 2.2 2.2
GA 0.7 0.4 -0.4 0.4 0.4 1.0 0.4 1.0 0.0 0.4 0.4 0.4 0.4 1.0 0.4 0.4
GC 2.5 2.1 1.3 2.1 2.1 2.1 2.1 2.1 1.7 2.1 0.8 2.1 2.1 2.1 2.1 2.1
GG 1.1 0.8 1.3 0.8 0.8 0.8 0.8 0.8 1.7 0.8 2.1 0.8 0.8 0.8 0.8 2.1
GU 2.5 2.1 1.3 2.1 2.1 2.1 2.1 2.1 1.7 2.1 0.8 2.1 2.1 2.1 2.1 2.1
UA 2.5 2.2 1.4 2.2 2.2 2.2 2.2 2.2 1.8 2.2 0.9 2.2 2.2 2.2 2.2 2.2
UC 2.5 2.2 2.0 2.2 2.2 2.2 2.2 2.2 2.4 2.2 0.9 2.2 2.2 2.2 2.2 2.2
UG 2.5 2.2 1.4 2.2 2.2 2.2 2.2 2.2 1.8 2.2 0.9 2.2 2.2 2.2 2.2 2.2
UU 2.4 1.4 0.6 1.4 1.4 1.4 1.4 1.4 1.0 1.4 1.4 1.4 1.4 1.4 1.4 1.4
# 5' ------> 3'
G X1 Y1 A
U X2 Y2 U
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G U U U U
A C G U A C G U A C G U A C G U
#----------------------------------------------------------------------------------------------------------------------------------
AA 3.4 3.0 2.4 3.0 3.4 3.4 3.4 3.4 2.5 3.0 1.9 3.0 3.4 3.1 3.4 3.2
AC 3.1 2.6 2.0 2.6 3.1 3.1 3.1 3.1 2.1 2.6 1.5 2.6 3.1 2.8 3.1 2.2
AG 2.7 2.2 1.6 2.2 2.7 3.3 2.7 3.3 1.7 2.2 2.4 2.2 2.7 3.0 2.7 1.8
AU 3.1 2.6 2.0 2.6 3.1 3.1 3.1 3.1 2.1 2.6 1.5 2.6 3.1 2.8 3.1 2.2
CA 3.1 2.6 2.0 2.6 3.1 3.1 3.1 3.1 2.1 2.6 1.5 2.6 3.1 2.8 3.1 2.2
CC 3.1 2.6 2.6 2.6 3.1 3.1 3.1 3.1 2.7 2.6 1.5 2.6 3.1 2.8 3.1 2.2
CG 3.1 2.6 2.0 2.6 3.1 3.1 3.1 3.1 2.1 2.6 1.5 2.6 3.1 2.8 3.1 2.2
CU 3.1 2.6 2.6 2.6 3.1 3.1 3.1 3.1 2.7 2.6 1.5 2.6 3.1 2.8 3.1 2.2
GA 2.3 1.8 1.2 1.8 2.3 2.9 2.3 2.9 1.3 1.8 2.0 1.8 2.3 2.6 2.3 1.4
GC 3.1 2.6 2.0 2.6 3.1 3.1 3.1 3.1 2.1 2.6 1.5 2.6 3.1 2.8 3.1 2.2
GG 1.8 1.3 2.0 1.3 1.8 1.8 1.8 1.8 2.1 1.3 2.8 1.3 1.8 1.5 1.8 2.2
GU 3.1 2.6 2.0 2.6 3.1 3.1 3.1 3.1 2.1 2.6 1.5 2.6 3.1 2.8 3.1 2.2
UA 3.1 2.6 2.0 2.6 3.1 3.1 3.1 3.1 2.1 2.6 1.5 2.6 3.1 2.8 3.1 2.2
UC 3.1 2.6 2.6 2.6 3.1 3.1 3.1 3.1 2.7 2.6 1.5 2.6 3.1 2.8 3.1 2.2
UG 3.1 2.6 2.0 2.6 3.1 3.1 3.1 3.1 2.1 2.6 1.5 2.6 3.1 2.8 3.1 2.2
UU 3.7 2.6 2.0 2.6 3.1 3.1 3.1 3.1 2.1 2.6 2.8 2.6 3.1 2.8 3.1 2.2
# 5' ------> 3'
G X1 Y1 C
U X2 Y2 G
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G U U U U
A C G U A C G U A C G U A C G U
#----------------------------------------------------------------------------------------------------------------------------------
AA 2.8 2.5 0.7 2.5 2.5 2.5 2.5 2.5 1.4 2.5 1.1 2.5 2.5 2.6 2.5 2.4
AC 2.4 2.2 0.4 2.2 2.1 2.2 2.1 2.2 1.0 2.2 0.8 2.2 2.1 2.2 2.1 1.4
AG 2.0 1.8 0.0 1.8 1.7 2.4 1.7 2.4 0.6 1.8 1.7 1.8 1.7 2.4 1.7 1.0
AU 2.4 2.2 0.4 2.2 2.1 2.2 2.1 2.2 1.0 2.2 0.8 2.2 2.1 2.2 2.1 1.4
CA 2.4 2.2 0.4 2.2 2.1 2.2 2.1 2.2 1.0 2.2 0.8 2.2 2.1 2.2 2.1 1.4
CC 2.4 2.2 1.0 2.2 2.1 2.2 2.1 2.2 1.6 2.2 0.8 2.2 2.1 2.2 2.1 1.4
CG 2.4 2.2 0.4 2.2 2.1 2.2 2.1 2.2 1.0 2.2 0.8 2.2 2.1 2.2 2.1 1.4
CU 2.4 2.2 1.0 2.2 2.1 2.2 2.1 2.2 1.6 2.2 0.8 2.2 2.1 2.2 2.1 1.4
GA 1.6 1.4 -0.4 1.4 1.3 2.0 1.3 2.0 0.2 1.4 1.3 1.4 1.3 2.0 1.3 0.6
GC 2.4 2.2 0.4 2.2 2.1 2.2 2.1 2.2 1.0 2.2 0.8 2.2 2.1 2.2 2.1 1.4
GG 1.1 0.9 0.4 0.9 0.8 0.9 0.8 0.9 1.0 0.9 2.1 0.9 0.8 0.9 0.8 1.4
GU 2.4 2.2 0.4 2.2 2.1 2.2 2.1 2.2 1.0 2.2 0.8 2.2 2.1 2.2 2.1 1.4
UA 2.4 2.2 0.4 2.2 2.1 2.2 2.1 2.2 1.0 2.2 0.8 2.2 2.1 2.2 2.1 1.4
UC 2.4 2.2 1.0 2.2 2.1 2.2 2.1 2.2 1.6 2.2 0.8 2.2 2.1 2.2 2.1 1.4
UG 2.4 2.2 0.4 2.2 2.1 2.2 2.1 2.2 1.0 2.2 0.8 2.2 2.1 2.2 2.1 1.4
UU 3.0 2.2 0.4 2.2 2.1 2.2 2.1 2.2 1.0 2.2 2.1 2.2 2.1 2.2 2.1 1.4
# 5' ------> 3'
G X1 Y1 G
U X2 Y2 C
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G U U U U
A C G U A C G U A C G U A C G U
#----------------------------------------------------------------------------------------------------------------------------------
AA 2.7 2.6 1.7 2.6 3.0 2.9 3.0 2.7 1.7 2.6 1.1 2.6 3.0 2.7 3.0 2.4
AC 2.3 2.2 1.3 2.2 2.7 2.5 2.7 2.4 1.3 2.2 0.8 2.2 2.7 2.4 2.7 1.5
AG 1.9 1.8 0.9 1.8 2.3 2.7 2.3 2.6 0.9 1.8 1.7 1.8 2.3 2.6 2.3 1.1
AU 2.3 2.2 1.3 2.2 2.7 2.5 2.7 2.4 1.3 2.2 0.8 2.2 2.7 2.4 2.7 1.5
CA 2.3 2.2 1.3 2.2 2.7 2.5 2.7 2.4 1.3 2.2 0.8 2.2 2.7 2.4 2.7 1.5
CC 2.3 2.2 1.9 2.2 2.7 2.5 2.7 2.4 1.9 2.2 0.8 2.2 2.7 2.4 2.7 1.5
CG 2.3 2.2 1.3 2.2 2.7 2.5 2.7 2.4 1.3 2.2 0.8 2.2 2.7 2.4 2.7 1.5
CU 2.3 2.2 1.9 2.2 2.7 2.5 2.7 2.4 1.9 2.2 0.8 2.2 2.7 2.4 2.7 1.5
GA 1.5 1.4 0.5 1.4 1.9 2.3 1.9 2.2 0.5 1.4 1.3 1.4 1.9 2.2 1.9 0.7
GC 2.3 2.2 1.3 2.2 2.7 2.5 2.7 2.4 1.3 2.2 0.8 2.2 2.7 2.4 2.7 1.5
GG 1.0 0.9 1.3 0.9 1.4 1.2 1.4 1.1 1.3 0.9 2.1 0.9 1.4 1.1 1.4 1.5
GU 2.3 2.2 1.3 2.2 2.7 2.5 2.7 2.4 1.3 2.2 0.8 2.2 2.7 2.4 2.7 1.5
UA 2.3 2.2 1.3 2.2 2.7 2.5 2.7 2.4 1.3 2.2 0.8 2.2 2.7 2.4 2.7 1.5
UC 2.3 2.2 1.9 2.2 2.7 2.5 2.7 2.4 1.9 2.2 0.8 2.2 2.7 2.4 2.7 1.5
UG 2.3 2.2 1.3 2.2 2.7 2.5 2.7 2.4 1.3 2.2 0.8 2.2 2.7 2.4 2.7 1.5
UU 2.9 2.2 1.3 2.2 2.7 2.5 2.7 2.4 1.3 2.2 2.1 2.2 2.7 2.4 2.7 1.5
# 5' ------> 3'
G X1 Y1 G
U X2 Y2 U
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G U U U U
A C G U A C G U A C G U A C G U
#----------------------------------------------------------------------------------------------------------------------------------
AA 3.6 3.4 2.2 3.4 3.4 3.4 3.4 3.4 3.7 3.4 2.1 3.4 3.4 3.4 3.4 4.0
AC 2.7 3.1 1.7 3.1 3.1 3.1 3.1 3.1 3.4 3.1 1.8 3.1 3.1 3.1 3.1 3.1
AG 3.6 2.7 1.3 2.7 2.7 3.3 2.7 3.3 3.0 2.7 2.7 2.7 2.7 3.3 2.7 2.7
AU 2.7 3.1 1.7 3.1 3.1 3.1 3.1 3.1 3.4 3.1 1.8 3.1 3.1 3.1 3.1 3.1
CA 2.7 3.1 1.7 3.1 3.1 3.1 3.1 3.1 3.4 3.1 1.8 3.1 3.1 3.1 3.1 3.1
CC 2.7 3.1 2.3 3.1 3.1 3.1 3.1 3.1 4.0 3.1 1.8 3.1 3.1 3.1 3.1 3.1
CG 2.7 3.1 1.7 3.1 3.1 3.1 3.1 3.1 3.4 3.1 1.8 3.1 3.1 3.1 3.1 3.1
CU 2.7 3.1 2.3 3.1 3.1 3.1 3.1 3.1 4.0 3.1 1.8 3.1 3.1 3.1 3.1 3.1
GA 1.9 2.3 0.2 2.3 2.3 2.9 2.3 2.9 2.6 2.3 2.3 2.3 2.3 2.9 2.3 2.3
GC 2.7 3.1 1.7 3.1 3.1 3.1 3.1 3.1 3.4 3.1 1.8 3.1 3.1 3.1 3.1 3.1
GG 1.4 1.8 1.7 1.8 1.8 1.8 1.8 1.8 3.4 1.8 3.1 1.8 1.8 1.8 1.8 3.1
GU 2.7 3.1 1.7 3.1 3.1 3.1 3.1 3.1 3.4 3.1 1.8 3.1 3.1 3.1 3.1 3.1
UA 2.7 3.1 1.7 3.1 3.1 3.1 3.1 3.1 3.4 3.1 1.8 3.1 3.1 3.1 3.1 3.1
UC 2.7 3.1 2.3 3.1 3.1 3.1 3.1 3.1 4.0 3.1 1.8 3.1 3.1 3.1 3.1 3.1
UG 2.7 3.1 1.7 3.1 3.1 3.1 3.1 3.1 3.4 3.1 1.8 3.1 3.1 3.1 3.1 3.1
UU 3.3 3.1 1.7 3.1 3.1 3.1 3.1 3.1 3.4 3.1 3.1 3.1 3.1 3.1 3.1 3.1
# 5' ------> 3'
G X1 Y1 U
U X2 Y2 A
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G U U U U
A C G U A C G U A C G U A C G U
#----------------------------------------------------------------------------------------------------------------------------------
AA 3.4 3.2 2.2 3.2 3.3 3.2 3.3 3.2 2.9 3.2 1.7 3.2 3.3 3.2 3.3 2.9
AC 3.1 2.8 1.8 2.8 2.9 2.9 2.9 2.9 2.5 2.8 1.3 2.8 2.9 2.9 2.9 2.0
AG 2.7 2.4 1.4 2.4 2.5 3.1 2.5 3.1 2.1 2.4 2.2 2.4 2.5 3.1 2.5 1.6
AU 3.1 2.8 1.8 2.8 2.9 2.9 2.9 2.9 2.5 2.8 1.3 2.8 2.9 2.9 2.9 2.0
CA 3.1 2.8 1.8 2.8 2.9 2.9 2.9 2.9 2.5 2.8 1.3 2.8 2.9 2.9 2.9 2.0
CC 3.1 2.8 2.4 2.8 2.9 2.9 2.9 2.9 3.1 2.8 1.3 2.8 2.9 2.9 2.9 2.0
CG 3.1 2.8 1.8 2.8 2.9 2.9 2.9 2.9 2.5 2.8 1.3 2.8 2.9 2.9 2.9 2.0
CU 3.1 2.8 2.4 2.8 2.9 2.9 2.9 2.9 3.1 2.8 1.3 2.8 2.9 2.9 2.9 2.0
GA 2.3 2.0 1.0 2.0 2.1 2.7 2.1 2.7 1.7 2.0 1.8 2.0 2.1 2.7 2.1 1.2
GC 3.1 2.8 1.8 2.8 2.9 2.9 2.9 2.9 2.5 2.8 1.3 2.8 2.9 2.9 2.9 2.0
GG 1.8 1.5 1.8 1.5 1.6 1.6 1.6 1.6 2.5 1.5 2.6 1.5 1.6 1.6 1.6 2.0
GU 3.1 2.8 1.8 2.8 2.9 2.9 2.9 2.9 2.5 2.8 1.3 2.8 2.9 2.9 2.9 2.0
UA 3.1 2.8 1.8 2.8 2.9 2.9 2.9 2.9 2.5 2.8 1.3 2.8 2.9 2.9 2.9 2.0
UC 3.1 2.8 2.4 2.8 2.9 2.9 2.9 2.9 3.1 2.8 1.3 2.8 2.9 2.9 2.9 2.0
UG 3.1 2.8 1.8 2.8 2.9 2.9 2.9 2.9 2.5 2.8 1.3 2.8 2.9 2.9 2.9 2.0
UU 3.7 2.8 1.8 2.8 2.9 2.9 2.9 2.9 2.5 2.8 2.6 2.8 2.9 2.9 2.9 2.0
# 5' ------> 3'
G X1 Y1 U
U X2 Y2 G
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G U U U U
A C G U A C G U A C G U A C G U
#----------------------------------------------------------------------------------------------------------------------------------
AA 4.1 3.7 2.9 3.7 3.7 3.7 3.7 3.7 3.3 3.7 2.4 3.7 3.7 3.7 3.7 4.3
AC 3.7 3.4 2.6 3.4 3.4 3.4 3.4 3.4 3.0 3.4 2.1 3.4 3.4 3.4 3.4 3.4
AG 3.3 3.0 2.2 3.0 3.0 3.6 3.0 3.6 2.6 3.0 3.0 3.0 3.0 3.6 3.0 3.0
AU 3.7 3.4 2.6 3.4 3.4 3.4 3.4 3.4 3.0 3.4 2.1 3.4 3.4 3.4 3.4 3.4
CA 3.7 3.4 2.6 3.4 3.4 3.4 3.4 3.4 3.0 3.4 2.1 3.4 3.4 3.4 3.4 3.4
CC 3.7 3.4 3.2 3.4 3.4 3.4 3.4 3.4 3.6 3.4 2.1 3.4 3.4 3.4 3.4 3.4
CG 3.7 3.4 2.6 3.4 3.4 3.4 3.4 3.4 3.0 3.4 2.1 3.4 3.4 3.4 3.4 3.4
CU 3.7 3.4 3.2 3.4 3.4 3.4 3.4 3.4 3.6 3.4 2.1 3.4 3.4 3.4 3.4 3.4
GA 2.9 2.6 1.8 2.6 2.6 3.2 2.6 3.2 2.2 2.6 2.6 2.6 2.6 3.2 2.6 2.6
GC 3.7 3.4 2.6 3.4 3.4 3.4 3.4 3.4 3.0 3.4 2.1 3.4 3.4 3.4 3.4 3.4
GG 2.4 2.1 2.6 2.1 2.1 2.1 2.1 2.1 3.0 2.1 3.4 2.1 2.1 2.1 2.1 3.4
GU 3.7 3.4 2.6 3.4 3.4 3.4 3.4 3.4 3.0 3.4 2.1 3.4 3.4 3.4 3.4 3.4
UA 3.7 3.4 2.6 3.4 3.4 3.4 3.4 3.4 3.0 3.4 2.1 3.4 3.4 3.4 3.4 3.4
UC 3.7 3.4 3.2 3.4 3.4 3.4 3.4 3.4 3.6 3.4 2.1 3.4 3.4 3.4 3.4 3.4
UG 3.7 3.4 2.6 3.4 3.4 3.4 3.4 3.4 3.0 3.4 2.1 3.4 3.4 3.4 3.4 3.4
UU 4.3 3.4 2.6 3.4 3.4 3.4 3.4 3.4 3.0 3.4 3.4 3.4 3.4 3.4 3.4 3.4
# 5' ------> 3'
U X1 Y1 A
A X2 Y2 U
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G U U U U
A C G U A C G U A C G U A C G U
#----------------------------------------------------------------------------------------------------------------------------------
AA 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 1.8 2.3 1.2 2.3 2.8 2.5 2.8 2.5
AC 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 1.8 2.3 1.2 2.3 2.8 2.5 2.8 1.9
AG 1.8 1.4 0.8 1.4 1.8 2.4 1.8 2.4 0.9 1.4 1.6 1.4 1.8 2.1 1.8 1.0
AU 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 1.8 2.3 1.2 2.3 2.8 2.5 2.8 1.9
CA 2.3 1.9 1.3 1.9 2.3 2.3 2.3 2.3 1.4 1.9 0.8 1.9 2.3 2.0 2.3 1.5
CC 2.8 2.3 2.3 2.3 2.8 2.8 2.8 2.8 2.4 2.3 1.2 2.3 2.8 2.5 2.8 1.9
CG 2.3 1.9 1.3 1.9 2.3 2.3 2.3 2.3 1.4 1.9 0.8 1.9 2.3 2.0 2.3 1.5
CU 2.5 2.0 2.0 2.0 2.5 2.5 2.5 2.5 2.1 2.0 0.9 2.0 2.5 2.2 2.5 1.6
GA 1.7 1.3 0.7 1.3 1.7 2.3 1.7 2.3 0.8 1.3 1.5 1.3 1.7 2.0 1.7 0.9
GC 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 1.8 2.3 1.2 2.3 2.8 2.5 2.8 1.9
GG 1.2 0.8 1.5 0.8 1.2 1.2 1.2 1.2 1.6 0.8 2.3 0.8 1.2 0.9 1.2 1.7
GU 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 1.8 2.3 1.2 2.3 2.8 2.5 2.8 1.9
UA 2.3 1.9 1.3 1.9 2.3 2.3 2.3 2.3 1.4 1.9 0.8 1.9 2.3 2.0 2.3 1.5
UC 2.8 2.3 2.3 2.3 2.8 2.8 2.8 2.8 2.4 2.3 1.2 2.3 2.8 2.5 2.8 1.9
UG 2.3 1.9 1.3 1.9 2.3 2.3 2.3 2.3 1.4 1.9 0.8 1.9 2.3 2.0 2.3 1.5
UU 2.5 1.5 0.9 1.5 1.9 1.9 1.9 1.9 1.0 1.5 1.7 1.5 1.9 1.6 1.9 1.1
# 5' ------> 3'
U X1 Y1 C
A X2 Y2 G
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G U U U U
A C G U A C G U A C G U A C G U
#----------------------------------------------------------------------------------------------------------------------------------
AA 2.1 1.9 0.1 1.9 1.8 1.9 1.8 1.9 0.7 1.9 0.5 1.9 1.8 1.9 1.8 1.7
AC 2.1 1.9 0.1 1.9 1.8 1.9 1.8 1.9 0.7 1.9 0.5 1.9 1.8 1.9 1.8 1.1
AG 1.2 0.9 -0.8 0.9 0.9 1.5 0.9 1.5 -0.2 0.9 0.8 0.9 0.9 1.6 0.9 0.2
AU 2.1 1.9 0.1 1.9 1.8 1.9 1.8 1.9 0.7 1.9 0.5 1.9 1.8 1.9 1.8 1.1
CA 1.7 1.4 -0.3 1.4 1.4 1.4 1.4 1.4 0.3 1.4 0.0 1.4 1.4 1.5 1.4 0.7
CC 2.1 1.9 0.7 1.9 1.8 1.9 1.8 1.9 1.3 1.9 0.5 1.9 1.8 1.9 1.8 1.1
CG 1.7 1.4 -0.3 1.4 1.4 1.4 1.4 1.4 0.3 1.4 0.0 1.4 1.4 1.5 1.4 0.7
CU 1.8 1.6 0.4 1.6 1.5 1.6 1.5 1.6 1.0 1.6 0.2 1.6 1.5 1.6 1.5 0.8
GA 1.1 0.8 -0.9 0.8 0.8 1.4 0.8 1.4 -0.3 0.8 0.7 0.8 0.8 1.5 0.8 0.1
GC 2.1 1.9 0.1 1.9 1.8 1.9 1.8 1.9 0.7 1.9 0.5 1.9 1.8 1.9 1.8 1.1
GG 0.6 0.3 -0.1 0.3 0.3 0.3 0.3 0.3 0.5 0.3 1.5 0.3 0.3 0.4 0.3 0.9
GU 2.1 1.9 0.1 1.9 1.8 1.9 1.8 1.9 0.7 1.9 0.5 1.9 1.8 1.9 1.8 1.1
UA 1.7 1.4 -0.3 1.4 1.4 1.4 1.4 1.4 0.3 1.4 0.0 1.4 1.4 1.5 1.4 0.7
UC 2.1 1.9 0.7 1.9 1.8 1.9 1.8 1.9 1.3 1.9 0.5 1.9 1.8 1.9 1.8 1.1
UG 1.7 1.4 -0.3 1.4 1.4 1.4 1.4 1.4 0.3 1.4 0.0 1.4 1.4 1.5 1.4 0.7
UU 1.9 1.0 -0.7 1.0 1.0 1.0 1.0 1.0 -0.1 1.0 0.9 1.0 1.0 1.1 1.0 0.3
# 5' ------> 3'
U X1 Y1 G
A X2 Y2 C
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G U U U U
A C G U A C G U A C G U A C G U
#----------------------------------------------------------------------------------------------------------------------------------
AA 2.0 1.9 1.0 1.9 2.4 2.2 2.4 2.1 1.0 1.9 0.5 1.9 2.4 2.1 2.4 1.8
AC 2.0 1.9 1.0 1.9 2.4 2.2 2.4 2.1 1.0 1.9 0.5 1.9 2.4 2.1 2.4 1.2
AG 1.0 1.0 0.1 1.0 1.4 1.9 1.4 1.7 0.1 1.0 0.8 1.0 1.4 1.7 1.4 0.2
AU 2.0 1.9 1.0 1.9 2.4 2.2 2.4 2.1 1.0 1.9 0.5 1.9 2.4 2.1 2.4 1.2
CA 1.5 1.5 0.6 1.5 1.9 1.8 1.9 1.6 0.6 1.5 0.0 1.5 1.9 1.6 1.9 0.7
CC 2.0 1.9 1.6 1.9 2.4 2.2 2.4 2.1 1.6 1.9 0.5 1.9 2.4 2.1 2.4 1.2
CG 1.5 1.5 0.6 1.5 1.9 1.8 1.9 1.6 0.6 1.5 0.0 1.5 1.9 1.6 1.9 0.7
CU 1.7 1.6 1.3 1.6 2.1 1.9 2.1 1.8 1.3 1.6 0.2 1.6 2.1 1.8 2.1 0.9
GA 0.9 0.9 0.0 0.9 1.3 1.8 1.3 1.6 0.0 0.9 0.7 0.9 1.3 1.6 1.3 0.1
GC 2.0 1.9 1.0 1.9 2.4 2.2 2.4 2.1 1.0 1.9 0.5 1.9 2.4 2.1 2.4 1.2
GG 0.4 0.4 0.8 0.4 0.8 0.7 0.8 0.5 0.8 0.4 1.5 0.4 0.8 0.5 0.8 0.9
GU 2.0 1.9 1.0 1.9 2.4 2.2 2.4 2.1 1.0 1.9 0.5 1.9 2.4 2.1 2.4 1.2
UA 1.5 1.5 0.6 1.5 1.9 1.8 1.9 1.6 0.6 1.5 0.0 1.5 1.9 1.6 1.9 0.7
UC 2.0 1.9 1.6 1.9 2.4 2.2 2.4 2.1 1.6 1.9 0.5 1.9 2.4 2.1 2.4 1.2
UG 1.5 1.5 0.6 1.5 1.9 1.8 1.9 1.6 0.6 1.5 0.0 1.5 1.9 1.6 1.9 0.7
UU 1.7 1.1 0.2 1.1 1.5 1.4 1.5 1.2 0.2 1.1 0.9 1.1 1.5 1.2 1.5 0.3
# 5' ------> 3'
U X1 Y1 G
A X2 Y2 U
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G U U U U
A C G U A C G U A C G U A C G U
#----------------------------------------------------------------------------------------------------------------------------------
AA 2.4 2.8 1.4 2.8 2.8 2.8 2.8 2.8 3.1 2.8 1.5 2.8 2.8 2.8 2.8 3.4
AC 2.4 2.8 1.4 2.8 2.8 2.8 2.8 2.8 3.1 2.8 1.5 2.8 2.8 2.8 2.8 2.8
AG 1.5 1.8 0.5 1.8 1.8 2.4 1.8 2.4 2.1 1.8 1.8 1.8 1.8 2.4 1.8 1.8
AU 2.4 2.8 1.4 2.8 2.8 2.8 2.8 2.8 3.1 2.8 1.5 2.8 2.8 2.8 2.8 2.8
CA 2.0 2.3 1.0 2.3 2.3 2.3 2.3 2.3 2.6 2.3 1.0 2.3 2.3 2.3 2.3 2.3
CC 2.4 2.8 2.0 2.8 2.8 2.8 2.8 2.8 3.7 2.8 1.5 2.8 2.8 2.8 2.8 2.8
CG 2.0 2.3 1.0 2.3 2.3 2.3 2.3 2.3 2.6 2.3 1.0 2.3 2.3 2.3 2.3 2.3
CU 2.1 2.5 1.7 2.5 2.5 2.5 2.5 2.5 3.4 2.5 1.2 2.5 2.5 2.5 2.5 2.5
GA 1.4 1.7 0.4 1.7 1.7 2.3 1.7 2.3 2.0 1.7 1.7 1.7 1.7 2.3 1.7 1.7
GC 2.4 2.8 1.4 2.8 2.8 2.8 2.8 2.8 3.1 2.8 1.5 2.8 2.8 2.8 2.8 2.8
GG 0.9 1.2 1.2 1.2 1.2 1.2 1.2 1.2 2.8 1.2 2.5 1.2 1.2 1.2 1.2 2.5
GU 2.4 2.8 1.4 2.8 2.8 2.8 2.8 2.8 3.1 2.8 1.5 2.8 2.8 2.8 2.8 2.8
UA 2.0 2.3 1.0 2.3 2.3 2.3 2.3 2.3 2.6 2.3 1.0 2.3 2.3 2.3 2.3 2.3
UC 2.4 2.8 2.0 2.8 2.8 2.8 2.8 2.8 3.7 2.8 1.5 2.8 2.8 2.8 2.8 2.8
UG 2.0 2.3 1.0 2.3 2.3 2.3 2.3 2.3 2.6 2.3 1.0 2.3 2.3 2.3 2.3 2.3
UU 2.2 1.9 0.6 1.9 1.9 1.9 1.9 1.9 2.2 1.9 1.9 1.9 1.9 1.9 1.9 1.9
# 5' ------> 3'
U X1 Y1 U
A X2 Y2 A
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G U U U U
A C G U A C G U A C G U A C G U
#----------------------------------------------------------------------------------------------------------------------------------
AA 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.2 2.5 1.0 2.5 2.6 2.6 2.6 2.3
AC 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.2 2.5 1.0 2.5 2.6 2.6 2.6 1.7
AG 1.8 1.6 0.6 1.6 1.7 2.2 1.7 2.2 1.3 1.6 1.4 1.6 1.7 2.2 1.7 0.7
AU 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.2 2.5 1.0 2.5 2.6 2.6 2.6 1.7
CA 2.3 2.1 1.1 2.1 2.2 2.1 2.2 2.1 1.8 2.1 0.6 2.1 2.2 2.1 2.2 1.2
CC 2.8 2.5 2.1 2.5 2.6 2.6 2.6 2.6 2.8 2.5 1.0 2.5 2.6 2.6 2.6 1.7
CG 2.3 2.1 1.1 2.1 2.2 2.1 2.2 2.1 1.8 2.1 0.6 2.1 2.2 2.1 2.2 1.2
CU 2.5 2.2 1.8 2.2 2.3 2.3 2.3 2.3 2.5 2.2 0.7 2.2 2.3 2.3 2.3 1.4
GA 1.7 1.5 0.5 1.5 1.6 2.1 1.6 2.1 1.2 1.5 1.3 1.5 1.6 2.1 1.6 0.6
GC 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.2 2.5 1.0 2.5 2.6 2.6 2.6 1.7
GG 1.2 1.0 1.3 1.0 1.1 1.0 1.1 1.0 2.0 1.0 2.1 1.0 1.1 1.0 1.1 1.4
GU 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.2 2.5 1.0 2.5 2.6 2.6 2.6 1.7
UA 2.3 2.1 1.1 2.1 2.2 2.1 2.2 2.1 1.8 2.1 0.6 2.1 2.2 2.1 2.2 1.2
UC 2.8 2.5 2.1 2.5 2.6 2.6 2.6 2.6 2.8 2.5 1.0 2.5 2.6 2.6 2.6 1.7
UG 2.3 2.1 1.1 2.1 2.2 2.1 2.2 2.1 1.8 2.1 0.6 2.1 2.2 2.1 2.2 1.2
UU 2.5 1.7 0.7 1.7 1.8 1.7 1.8 1.7 1.4 1.7 1.5 1.7 1.8 1.7 1.8 0.8
# 5' ------> 3'
U X1 Y1 U
A X2 Y2 G
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G U U U U
A C G U A C G U A C G U A C G U
#----------------------------------------------------------------------------------------------------------------------------------
AA 3.4 3.1 2.3 3.1 3.1 3.1 3.1 3.1 2.7 3.1 1.8 3.1 3.1 3.1 3.1 3.7
AC 3.4 3.1 2.3 3.1 3.1 3.1 3.1 3.1 2.7 3.1 1.8 3.1 3.1 3.1 3.1 3.1
AG 2.5 2.1 1.3 2.1 2.1 2.7 2.1 2.7 1.7 2.1 2.1 2.1 2.1 2.7 2.1 2.1
AU 3.4 3.1 2.3 3.1 3.1 3.1 3.1 3.1 2.7 3.1 1.8 3.1 3.1 3.1 3.1 3.1
CA 3.0 2.6 1.8 2.6 2.6 2.6 2.6 2.6 2.2 2.6 1.3 2.6 2.6 2.6 2.6 2.6
CC 3.4 3.1 2.9 3.1 3.1 3.1 3.1 3.1 3.3 3.1 1.8 3.1 3.1 3.1 3.1 3.1
CG 3.0 2.6 1.8 2.6 2.6 2.6 2.6 2.6 2.2 2.6 1.3 2.6 2.6 2.6 2.6 2.6
CU 3.1 2.8 2.6 2.8 2.8 2.8 2.8 2.8 3.0 2.8 1.5 2.8 2.8 2.8 2.8 2.8
GA 2.4 2.0 1.2 2.0 2.0 2.6 2.0 2.6 1.6 2.0 2.0 2.0 2.0 2.6 2.0 2.0
GC 3.4 3.1 2.3 3.1 3.1 3.1 3.1 3.1 2.7 3.1 1.8 3.1 3.1 3.1 3.1 3.1
GG 1.9 1.5 2.0 1.5 1.5 1.5 1.5 1.5 2.4 1.5 2.8 1.5 1.5 1.5 1.5 2.8
GU 3.4 3.1 2.3 3.1 3.1 3.1 3.1 3.1 2.7 3.1 1.8 3.1 3.1 3.1 3.1 3.1
UA 3.0 2.6 1.8 2.6 2.6 2.6 2.6 2.6 2.2 2.6 1.3 2.6 2.6 2.6 2.6 2.6
UC 3.4 3.1 2.9 3.1 3.1 3.1 3.1 3.1 3.3 3.1 1.8 3.1 3.1 3.1 3.1 3.1
UG 3.0 2.6 1.8 2.6 2.6 2.6 2.6 2.6 2.2 2.6 1.3 2.6 2.6 2.6 2.6 2.6
UU 3.2 2.2 1.4 2.2 2.2 2.2 2.2 2.2 1.8 2.2 2.2 2.2 2.2 2.2 2.2 2.2
# 5' ------> 3'
U X1 Y1 A
G X2 Y2 U
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G U U U U
A C G U A C G U A C G U A C G U
#----------------------------------------------------------------------------------------------------------------------------------
AA 2.4 2.0 1.4 2.0 2.4 2.4 2.4 2.4 1.5 2.0 0.9 2.0 2.4 2.1 2.4 2.2
AC 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 1.8 2.3 1.2 2.3 2.8 2.5 2.8 1.9
AG 3.1 2.6 2.0 2.6 3.1 3.7 3.1 3.7 2.1 2.6 2.8 2.6 3.1 3.4 3.1 2.2
AU 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 1.8 2.3 1.2 2.3 2.8 2.5 2.8 1.9
CA 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 1.8 2.3 1.2 2.3 2.8 2.5 2.8 1.9
CC 2.8 2.3 2.3 2.3 2.8 2.8 2.8 2.8 2.4 2.3 1.2 2.3 2.8 2.5 2.8 1.9
CG 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 1.8 2.3 1.2 2.3 2.8 2.5 2.8 1.9
CU 2.8 2.3 2.3 2.3 2.8 2.8 2.8 2.8 2.4 2.3 1.2 2.3 2.8 2.5 2.8 1.9
GA 1.4 1.0 0.4 1.0 1.4 2.0 1.4 2.0 0.5 1.0 1.2 1.0 1.4 1.7 1.4 0.6
GC 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 1.8 2.3 1.2 2.3 2.8 2.5 2.8 1.9
GG 1.5 1.0 1.7 1.0 1.5 1.5 1.5 1.5 1.8 1.0 2.5 1.0 1.5 1.2 1.5 1.9
GU 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 1.8 2.3 1.2 2.3 2.8 2.5 2.8 1.9
UA 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 1.8 2.3 1.2 2.3 2.8 2.5 2.8 1.9
UC 2.8 2.3 2.3 2.3 2.8 2.8 2.8 2.8 2.4 2.3 1.2 2.3 2.8 2.5 2.8 1.9
UG 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 1.8 2.3 1.2 2.3 2.8 2.5 2.8 1.9
UU 3.4 2.3 1.7 2.3 2.8 2.8 2.8 2.8 1.8 2.3 2.5 2.3 2.8 2.5 2.8 1.9
# 5' ------> 3'
U X1 Y1 C
G X2 Y2 G
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G U U U U
A C G U A C G U A C G U A C G U
#----------------------------------------------------------------------------------------------------------------------------------
AA 1.9 1.5 -0.2 1.5 1.5 1.5 1.5 1.5 0.4 1.5 0.1 1.5 1.5 1.6 1.5 1.4
AC 2.1 1.9 0.1 1.9 1.8 1.9 1.8 1.9 0.7 1.9 0.5 1.9 1.8 1.9 1.8 1.1
AG 2.4 2.2 0.4 2.2 2.1 2.8 2.1 2.8 1.0 2.2 2.1 2.2 2.1 2.8 2.1 1.4
AU 2.1 1.9 0.1 1.9 1.8 1.9 1.8 1.9 0.7 1.9 0.5 1.9 1.8 1.9 1.8 1.1
CA 2.1 1.9 0.1 1.9 1.8 1.9 1.8 1.9 0.7 1.9 0.5 1.9 1.8 1.9 1.8 1.1
CC 2.1 1.9 0.7 1.9 1.8 1.9 1.8 1.9 1.3 1.9 0.5 1.9 1.8 1.9 1.8 1.1
CG 2.1 1.9 0.1 1.9 1.8 1.9 1.8 1.9 0.7 1.9 0.5 1.9 1.8 1.9 1.8 1.1
CU 2.1 1.9 0.7 1.9 1.8 1.9 1.8 1.9 1.3 1.9 0.5 1.9 1.8 1.9 1.8 1.1
GA 0.8 0.5 -1.2 0.5 0.5 1.1 0.5 1.1 -0.6 0.5 0.4 0.5 0.5 1.2 0.5 -0.2
GC 2.1 1.9 0.1 1.9 1.8 1.9 1.8 1.9 0.7 1.9 0.5 1.9 1.8 1.9 1.8 1.1
GG 0.8 0.6 0.1 0.6 0.5 0.6 0.5 0.6 0.7 0.6 1.8 0.6 0.5 0.6 0.5 1.1
GU 2.1 1.9 0.1 1.9 1.8 1.9 1.8 1.9 0.7 1.9 0.5 1.9 1.8 1.9 1.8 1.1
UA 2.1 1.9 0.1 1.9 1.8 1.9 1.8 1.9 0.7 1.9 0.5 1.9 1.8 1.9 1.8 1.1
UC 2.1 1.9 0.7 1.9 1.8 1.9 1.8 1.9 1.3 1.9 0.5 1.9 1.8 1.9 1.8 1.1
UG 2.1 1.9 0.1 1.9 1.8 1.9 1.8 1.9 0.7 1.9 0.5 1.9 1.8 1.9 1.8 1.1
UU 2.7 1.9 0.1 1.9 1.8 1.9 1.8 1.9 0.7 1.9 1.8 1.9 1.8 1.9 1.8 1.1
# 5' ------> 3'
U X1 Y1 G
G X2 Y2 C
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G U U U U
A C G U A C G U A C G U A C G U
#----------------------------------------------------------------------------------------------------------------------------------
AA 1.6 1.6 0.7 1.6 2.0 1.9 2.0 1.7 0.7 1.6 0.1 1.6 2.0 1.7 2.0 1.4
AC 2.0 1.9 1.0 1.9 2.4 2.2 2.4 2.1 1.0 1.9 0.5 1.9 2.4 2.1 2.4 1.2
AG 2.3 2.2 1.3 2.2 2.7 3.1 2.7 3.0 1.3 2.2 2.1 2.2 2.7 3.0 2.7 1.5
AU 2.0 1.9 1.0 1.9 2.4 2.2 2.4 2.1 1.0 1.9 0.5 1.9 2.4 2.1 2.4 1.2
CA 2.0 1.9 1.0 1.9 2.4 2.2 2.4 2.1 1.0 1.9 0.5 1.9 2.4 2.1 2.4 1.2
CC 2.0 1.9 1.6 1.9 2.4 2.2 2.4 2.1 1.6 1.9 0.5 1.9 2.4 2.1 2.4 1.2
CG 2.0 1.9 1.0 1.9 2.4 2.2 2.4 2.1 1.0 1.9 0.5 1.9 2.4 2.1 2.4 1.2
CU 2.0 1.9 1.6 1.9 2.4 2.2 2.4 2.1 1.6 1.9 0.5 1.9 2.4 2.1 2.4 1.2
GA 0.6 0.6 -0.3 0.6 1.0 1.5 1.0 1.3 -0.3 0.6 0.4 0.6 1.0 1.3 1.0 -0.1
GC 2.0 1.9 1.0 1.9 2.4 2.2 2.4 2.1 1.0 1.9 0.5 1.9 2.4 2.1 2.4 1.2
GG 0.7 0.6 1.0 0.6 1.1 0.9 1.1 0.8 1.0 0.6 1.8 0.6 1.1 0.8 1.1 1.2
GU 2.0 1.9 1.0 1.9 2.4 2.2 2.4 2.1 1.0 1.9 0.5 1.9 2.4 2.1 2.4 1.2
UA 2.0 1.9 1.0 1.9 2.4 2.2 2.4 2.1 1.0 1.9 0.5 1.9 2.4 2.1 2.4 1.2
UC 2.0 1.9 1.6 1.9 2.4 2.2 2.4 2.1 1.6 1.9 0.5 1.9 2.4 2.1 2.4 1.2
UG 2.0 1.9 1.0 1.9 2.4 2.2 2.4 2.1 1.0 1.9 0.5 1.9 2.4 2.1 2.4 1.2
UU 2.6 1.9 1.0 1.9 2.4 2.2 2.4 2.1 1.0 1.9 1.8 1.9 2.4 2.1 2.4 1.2
# 5' ------> 3'
U X1 Y1 G
G X2 Y2 U
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G U U U U
A C G U A C G U A C G U A C G U
#----------------------------------------------------------------------------------------------------------------------------------
AA 2.1 2.4 1.1 2.4 2.4 2.4 2.4 2.4 2.7 2.4 1.1 2.4 2.4 2.4 2.4 3.0
AC 2.4 2.8 1.4 2.8 2.8 2.8 2.8 2.8 3.1 2.8 1.5 2.8 2.8 2.8 2.8 2.8
AG 2.7 3.1 1.7 3.1 3.1 3.7 3.1 3.7 3.4 3.1 3.1 3.1 3.1 3.7 3.1 3.1
AU 2.4 2.8 1.4 2.8 2.8 2.8 2.8 2.8 3.1 2.8 1.5 2.8 2.8 2.8 2.8 2.8
CA 2.4 2.8 1.4 2.8 2.8 2.8 2.8 2.8 3.1 2.8 1.5 2.8 2.8 2.8 2.8 2.8
CC 2.4 2.8 2.0 2.8 2.8 2.8 2.8 2.8 3.7 2.8 1.5 2.8 2.8 2.8 2.8 2.8
CG 2.4 2.8 1.4 2.8 2.8 2.8 2.8 2.8 3.1 2.8 1.5 2.8 2.8 2.8 2.8 2.8
CU 2.4 2.8 2.0 2.8 2.8 2.8 2.8 2.8 3.7 2.8 1.5 2.8 2.8 2.8 2.8 2.8
GA 1.1 1.4 0.1 1.4 1.4 2.0 1.4 2.0 1.7 1.4 1.4 1.4 1.4 2.0 1.4 1.4
GC 2.4 2.8 1.4 2.8 2.8 2.8 2.8 2.8 3.1 2.8 1.5 2.8 2.8 2.8 2.8 2.8
GG 1.1 1.5 1.4 1.5 1.5 1.5 1.5 1.5 3.1 1.5 2.8 1.5 1.5 1.5 1.5 2.8
GU 2.4 2.8 1.4 2.8 2.8 2.8 2.8 2.8 3.1 2.8 1.5 2.8 2.8 2.8 2.8 2.8
UA 2.4 2.8 1.4 2.8 2.8 2.8 2.8 2.8 3.1 2.8 1.5 2.8 2.8 2.8 2.8 2.8
UC 2.4 2.8 2.0 2.8 2.8 2.8 2.8 2.8 3.7 2.8 1.5 2.8 2.8 2.8 2.8 2.8
UG 2.4 2.8 1.4 2.8 2.8 2.8 2.8 2.8 3.1 2.8 1.5 2.8 2.8 2.8 2.8 2.8
UU 3.0 2.8 1.4 2.8 2.8 2.8 2.8 2.8 3.1 2.8 2.8 2.8 2.8 2.8 2.8 2.8
# 5' ------> 3'
U X1 Y1 U
G X2 Y2 A
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G U U U U
A C G U A C G U A C G U A C G U
#----------------------------------------------------------------------------------------------------------------------------------
AA 2.4 2.2 1.2 2.2 2.3 2.2 2.3 2.2 1.9 2.2 0.7 2.2 2.3 2.2 2.3 1.9
AC 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.2 2.5 1.0 2.5 2.6 2.6 2.6 1.7
AG 3.1 2.8 1.8 2.8 2.9 3.5 2.9 3.5 2.5 2.8 2.6 2.8 2.9 3.5 2.9 2.0
AU 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.2 2.5 1.0 2.5 2.6 2.6 2.6 1.7
CA 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.2 2.5 1.0 2.5 2.6 2.6 2.6 1.7
CC 2.8 2.5 2.1 2.5 2.6 2.6 2.6 2.6 2.8 2.5 1.0 2.5 2.6 2.6 2.6 1.7
CG 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.2 2.5 1.0 2.5 2.6 2.6 2.6 1.7
CU 2.8 2.5 2.1 2.5 2.6 2.6 2.6 2.6 2.8 2.5 1.0 2.5 2.6 2.6 2.6 1.7
GA 1.4 1.2 0.2 1.2 1.3 1.8 1.3 1.8 0.9 1.2 1.0 1.2 1.3 1.8 1.3 0.3
GC 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.2 2.5 1.0 2.5 2.6 2.6 2.6 1.7
GG 1.5 1.2 1.5 1.2 1.3 1.3 1.3 1.3 2.2 1.2 2.3 1.2 1.3 1.3 1.3 1.7
GU 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.2 2.5 1.0 2.5 2.6 2.6 2.6 1.7
UA 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.2 2.5 1.0 2.5 2.6 2.6 2.6 1.7
UC 2.8 2.5 2.1 2.5 2.6 2.6 2.6 2.6 2.8 2.5 1.0 2.5 2.6 2.6 2.6 1.7
UG 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.2 2.5 1.0 2.5 2.6 2.6 2.6 1.7
UU 3.4 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.2 2.5 2.3 2.5 2.6 2.6 2.6 1.7
# 5' ------> 3'
U X1 Y1 U
G X2 Y2 G
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G U U U U
A C G U A C G U A C G U A C G U
#----------------------------------------------------------------------------------------------------------------------------------
AA 3.6 2.7 1.9 2.7 2.7 2.7 2.7 2.7 3.6 2.7 1.4 2.7 2.7 2.7 2.7 3.3
AC 3.4 3.1 2.3 3.1 3.1 3.1 3.1 3.1 2.7 3.1 1.8 3.1 3.1 3.1 3.1 3.1
AG 3.7 3.4 2.6 3.4 3.4 4.0 3.4 4.0 3.0 3.4 3.4 3.4 3.4 4.0 3.4 3.4
AU 3.4 3.1 2.3 3.1 3.1 3.1 3.1 3.1 2.7 3.1 1.8 3.1 3.1 3.1 3.1 3.1
CA 3.4 3.1 2.3 3.1 3.1 3.1 3.1 3.1 2.7 3.1 1.8 3.1 3.1 3.1 3.1 3.1
CC 3.4 3.1 2.9 3.1 3.1 3.1 3.1 3.1 3.3 3.1 1.8 3.1 3.1 3.1 3.1 3.1
CG 3.4 3.1 2.3 3.1 3.1 3.1 3.1 3.1 2.7 3.1 1.8 3.1 3.1 3.1 3.1 3.1
CU 3.4 3.1 2.9 3.1 3.1 3.1 3.1 3.1 3.3 3.1 1.8 3.1 3.1 3.1 3.1 3.1
GA 2.2 1.7 0.2 1.7 1.7 2.3 1.7 2.3 1.3 1.7 1.7 1.7 1.7 2.3 1.7 1.7
GC 3.4 3.1 2.3 3.1 3.1 3.1 3.1 3.1 2.7 3.1 1.8 3.1 3.1 3.1 3.1 3.1
GG 2.1 1.8 2.3 1.8 1.8 1.8 1.8 1.8 2.7 1.8 3.1 1.8 1.8 1.8 1.8 3.1
GU 3.4 3.1 2.3 3.1 3.1 3.1 3.1 3.1 2.7 3.1 1.8 3.1 3.1 3.1 3.1 3.1
UA 3.4 3.1 2.3 3.1 3.1 3.1 3.1 3.1 2.7 3.1 1.8 3.1 3.1 3.1 3.1 3.1
UC 3.4 3.1 2.9 3.1 3.1 3.1 3.1 3.1 3.3 3.1 1.8 3.1 3.1 3.1 3.1 3.1
UG 3.4 3.1 2.3 3.1 3.1 3.1 3.1 3.1 2.7 3.1 1.8 3.1 3.1 3.1 3.1 3.1
UU 4.0 3.1 2.3 3.1 3.1 3.1 3.1 3.1 2.7 3.1 3.1 3.1 3.1 3.1 3.1 3.1